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Colostrum ResearchAthletic PerformanceMero A, et al. (1997) Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology . 83: 1144-1151. Sparling PB, Nieman DC, O'Connor PJ. (1993) Selected scientific aspects of marathon racing : an update on fluid replacement, immune function, psychological factors and the gender difference. Sports Medicine . 15: 116-132. Berk LS, Nieman DC, Youngberg WS, et al. (1989) The effect of long endurance running on natural killer cells in marathoners. Medicine and Science in Sports and Exercise . 22: 207-212. Antonio, J., Sanders, M. and Van Gammeren, D. The Effects of Bovine Colostrum Supplementation on Body Composition and Exercise Performance in Active Men and Women. Nutrition 17:243-247, 2001. General InformationBitzan MM, Gold BD, Philpott DJ, et al. (1998) Inhibition of Helicobacter pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. The Journal of Infectious Diseases . 177: 955-961. Cavalli-Sforza LT, Strata A. (1987) Double-blind study on the tolerance of four types of milk in lactose malabsorbers. Human Nutrition: Clinical Nutrition 40C: 19-30. Joseph M. and Flesch A. (1998) Research shows colostrum to be one of nature's most potent, broad-spectrum substances. Chiropractic Journal . Cenacchi T, Baggio C, and Palin E. (1987) Human tolerability of oral phosphatidylserine assessed through laboratory examinations. Clinical Trials Journal . 24. Ghidini A, Hicks C, Lapinski RH, Lockwood CJ. (1997) Morbidity in the preterm infant with mature lung indicies. American Journal of Perinatology . 14: 75-78. Jochims K, Kaup FJ, Drommer W. (1994) Immunoelectron microscopical demonstration of the absorption of colostral IgG by small intestinal enterocytes in newborn rats. Research in Veterinary Science . 57: 146-151. Efigenia M, Povoa B, Moraes-Santos T. (1997) Effect of heat treatment on the nutritional quality of milk proteins. International Dairy Journal . 7:609-612. Klagsbrun, M. (1978) Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts. Proceedings of the National Academy of Sciences, USA . 75: 5057-5061. Kume S, Tanabe S. (1993) Effect of parity on colostral mineral concentrations of holstein cows and value of colostrum as a mineral source for newborn calves. Journal of Dairy Science . 76:1654-1660. Le Dividich J, Herpin P, Paul E, Strullu F. (1997) Effect of fat content of colostrum on voluntary colostrum intake and fat utilization in newborn pigs. Journal of Animal Science . 75:707-713. Li-Chan E, Kummer A, Losso J, Kitts D, Nakai S. (1995) Stability of bovine immunoglobulins to thermal treatment and processing. Food Research International . 28: 9-16. Nitsch A, and Nitsch F. (1998) The clinical use of bovine colostrum. Journal of Orthomolecular Medicine . 13. Wit JN. (1998) Nutritional and functional characteristics of whey proteins in food products. Journal of Dairy Science . 81:597-608. Walker WA. (1999) What is the role of nucleotides and polyamines in breast milk? Acta Paediatrica . 88:1313-1315. McConnell MA, Brooks HJL, Borissenko MB, Buchan GA. A comparative study of immunoglobulin levels and anti-inflammatory activity in four milk products. Journal of Dairy Science , Publication forthcoming. Warny M, Fatima A, Bostwick E, et al. (1998) Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut . 44(2):212-7. Wieczorek Z, Zimecki M, Janusz M, Staroscik K, Lisowski J. (1979) Proline-rich polypeptide from ovine colostrum: its effect on skin permeability and on the immune system. Immunology . 36:879-881. Yamamoto A, Wada O, Suzuki H. (1987) Purification and properties of biologically active chromium complex from bovine colostrum. American Institute of Nutrition . 118(1):39-45. Zhang T, Iguchi K, Mochizzuki T, Hoshino M, Yanaihara C, Yanaihara N. (1990) Gonadotropin-releasing hormone-associated peptide immunoreactivity in bovine colostrum. Society for Experimental Biology and Medicine . 194(3):270-3. Growth FactorsAntonio J. (1998) Can bovine colostrum enhance levels of IGF-1? Muscle and Fitness . Ballard F, Wallace J, Francis G, Read L, Tomas F. (1996) Des (1-3) IGF-I: a truncated form of insulin-like growth factor-I. International Journal of Cellular Biology . 28:1085-1087. Bricker D. (1991) Colostrum: Implications for accelerated recovery in damaged muscle and cartilage, prevention of some pathogenic disease. The American Chiropractor . Burrin D, Davis T, Ebner S, Schoknecht P, Fiorotto M, Reeds P. (1997) Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs. American Society for Nutritional Sciences. 127(7):1284-9. Bhora F, Dunkin, B, Batzri S, et al. (1995) Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgery Res . 59:236-244. Burrin DG, Shulman RJ, Reeds PJ, Davis TA, Gravitt KR. (1992) Porcine colostrum and milk stimulate visceral organ and skeletal muscle protein synthesis in neonatal piglets. Journal of Nutrition . 122:1205-1213. Cass TL. Insuin-like growth factor-1 (IGF-1, Somatomedin C) blood levels are not associated with prostate specific antigen (PSA) levels or prostate cancer: A study of 749 patients. Medical College of Wisconsin , Milwaukee, WI www.worldhealth.net/news/prost-igf1/:1999 . Demarco C. (1998) Anti-aging breakthrough: Homeopathic growth factors. Let's Live . Francis G, Upton F, Ballard J, McNeil K, Wallace J. (1988) Insulin-like growth factors 1 and 2 in bovine colostrum. Journal of Biochemistry . 251:95-103. Fryburg D. (1995) Insulin and insulin-like growth factor 1 enhance human skeletal muschle protein anabolism during Hyperaminoacidemia by different mechanisms. Journal of Clinical Investigations 96:1722-1729. Francis G, Read L, Ballard J, et al. (1986) Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Journal of Biochemistry 233:207-213. Ginjala V, Pakkanen R. (1998) Determination of transforming growth factor-B1 (TGF-B1) and insulin-like growth factor 1 (IGF-1) in bovine colostrum samples. Journal of Immunoassay 19:195-207. Hadsell KL, Baumrucker CR, Kensinger RS. (1993) Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase. Journal of Endocrinology . 137:223-230. Juskevich J. (1990) Bovine Growth Hormone: Human Food Safety Evaluation. Science . 249:875-883. Kirkpatrick CH.(1993) Structural nature and functions of transfer factors. Annals New York Academy of Sciences . 685:362-8. Marcotty C, Frankenne F, Van Beeumen J, Maghuin-Rogister G, Hennen G. (1991) Insulin-like growth I (IGF-I) from cow colostrum: Purification and characterization. Growth Regulation . 1(2):56-61. Marquardt H, Lioubin MN, Ikeda T. (1987) Complete amino acid sequence of human transforming growth factor type beta 2. Journal of Biological Chemistry . 262:12127-12131. Miers W, Barrett E. (1998) The role of insulin and other hormones in the regulation of amino acid and protein metabolism in humans. Journal of Basic and Clinical Physiology and Pharmacolog y. 9(2-4):235-53. Noda K, Umeda M, Ono T. (1984) Transforming growth factor activity in human colostrum. Gann . 75:109-112. Nowak J, Olszewski J, Kozal E. (1994) Insulin and sugar concentration changes in mammary secretion in sheep during the periparturient period. Reprod. Nutritional Development . 34:3-8. Nowak J. (1990) Insulin and glucose concentration changes in newborn piglets after suckling the colostrum from insulin administered sows. Acta Physiol . 41(7):155-62. Nord J, Ma P, DiJohn D, Tzipori S, Tacket CO. (1990) Treatment with bovine hyperimmune colostrum cryptosporidial diarrhea in AIDS patients. AIDS . 4:581-584. Oda S, Satoh H, Sugawara T, et al. (1989) Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition. Comp. Biochemical Physiology . 94A:805-808. Pakkanen R, Aalto J. (1997) Review paper: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 7:285-297. Pakkanen R. (1998) Determination of transforming growth factor-ß2 (TGF-ß2) in bovine colostrum samples. Journal of Immunoassay. 19:23-37. Rosenthal S, Brown E, Brunetti A, Goldfine I. (1991) Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Molecular Endocinology. 5:678-684. Russell J, Feldman E. (1999) Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose. Horm Metab Res. 31:90-96. Sara VR, Hall K. (1990) Insulin-like growth factors and their binding proteins. Physiological Reviews. 70:591-606. Shimizu M, Webster C, Morgan DO, Blau HM, Roth RA. (1986) Insulin and insulin-like growth factor receptors and responses in cultured human muscle cells. American Journal of Physiology . 251:E611-5. Shing Y, Klagsbrun M. (1987)Purification and characterization of a bovine colostrum-derived growth factor. Molecular Endocrinology . 1:335-338. Skottner A, Arrhenius-Nyberg V, Kanje M, Fryklund L. (1990) Anabolic and tissue repair functions of recombinant insulin-like growth factor I. Acta Pediatric Scand . 367:63-66. Sporn M, Roberts A, Shull J, Smith J, Ward J. (1983) Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science . 219(4590): 1329-31. Tokuyama H, Tokuyama Y, Migita S. (1990) Isolation of two new proteins from bovine colostrum which stimulates epidermal growth factor-dependent colony formation of NRK-49F cells. Growth Factors . 3(2):105-14. Tokuyama Y. (1993) Purification and identification of TGF-B2-related growth factor from bovine colostrum. Journal of Dairy Research . 60:99-109. Tollefsen S, Lajara R, McCusker R, Clemmons D, Rotwein P. (1989) Insulin-like growth factors (IGF) in muscle development. Journal of Biological Chemistry . 264(23):13810-7. Tomas F, Knowles S, Owens P, et al. (1991 ) Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J. 276 ( Pt 2):547-54. Tokuyama, H. and Tokuyama, Y. (1989) Bovine colostric transforming growth factor-ß-like peptide that induces growth inhibition and changes in morphology of human osteogenic sarcoma cells (MG-63). Cell Biology International Reports 13:251-258. Ullman M, Ullman A, Sommerland H, Skottner A, Oldfors A. (1990) Effects of growth hormone on muscle regeneration and IGF-I concentration in old rats. Acta Physiological Scand 140:521-525. Shomali M, Wolfsthal S. (1997) The use of anti-aging hormones. Maryland Medical Journal 46:181-186. Watson DL, Francis GL, Ballard FJ. (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. Journal of Dairy Research 59:369-380. Immune FactorsBocci V, Von Bremen K, Corradeschi F, Luzzi E, Paulesu L. (1991) What is the role of cytokines in human colostrum? Journal of Biological Regulators and Homeostatic Agents . 3:121-124. Boesman-Finkelstein M. and Finkelstein R. (1989) Passive oral immunisation of children. Lancet . 2(8675):1336. Bogstedt AK, Johansen K, Hatta H, et al. (1996) Passive immunity against diarrhoea. Acta Paediatr . 85:125-128. Casswall T, Sarker S, Albert M, et al. (1998) Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Ailment Pharmacol Therapies 12:563-568. Davidson G, Whyte P, Daniels E, et al. (1989) Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet . 2(8665):709-12. Dichtelmuller W, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Clinical Biochemistry 28:19-23. Ebina T, Umezu K, Ohyama S, et al. (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet . 2(8357):1029-30. Feldmann M, Brennan F, Maini R. Role of cytokines in rheumatoid arthritis. Annual Review of Immunology 14 :397-440, 1996. Hanson LA, Ahlstedt S, Andersson B, et al. (1983) Mucosal Immunity. Annals New York Academy of Sciences 83:1-20. Boesman-Finkelsein M, Walton NE, Finkelstein RA. (1989) Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes. Infection and Immunity 57:1227-1234. Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. Journal of Infectious Diseases 156:158-166. Hirmo S, et al. (1998) Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Analytical Biochemistry 257:63-6. Hoffman M. (1992) Transferred immune cells may help fight viral infection. Immunology . 257(5067):166. Honorio-Franca A, Carvalho M, Isaac L, Trabulsi L, Carneiro-Sampaio M. (1997) Colostral mononuclear phagocytes are able to kill enteropathogenic Escherichia coli opsonized with colostral IgA. Scandavian Journal of Immunology . 46:59-66. Huppertz H, Rutkowski S, Busch D, Eisebit R, Lissner R, Karch H. (1999) Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E. coli, and E-coli expressing intimin and hemolysin. Journal of Pediatric Gastroenterology and Nutrition . 29:452-456. Janusz M, Lisowski J. (1993) Proline-rich polypeptide (PRP)-an immunomodulatory peptide from ovine colostrum. Archivum Immunologiae et Therapiae Experimentalis . 41:275-279. Jochims K, Kaup F, Drommer W, Pickel M. (1994) An immunoelectron microscopic investigation of colostral IgG absorption across the intestine of newborn calves. Research in Veterinary Science . 57:75-80. Kelly CP, et al. (1996) Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotixicity of C. difficile toxins. Antimicrobial Agents and Chemotherapy 40:373-379. Kelly G. (1999) Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alternative Medicine Review . 4(2):96-103. Khazenson L, Gennad'eva T, Roshchin V, Krasheniuk A, Semenova N. (1980) Activity of bovine colostral IgG in the human digestive tract. ZH Mikrobiol Epidemiol Immunobiol 9:101-106. Kohl S, Malloy, M, Pickering L, Morriss F, Adcock E, Walters D. (1978) Human colostral cytotoxicity: I. Antibody-dependent cellular cytotoxicity against herpes simplex viral-infected cells mediated by colostral cells. Journal of Clinical Laboratory Immunology . 1:221-224. Korhonen H, Suvaoja EL, Ahola-Luttilia H, et al. (1995) Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobactor pylori. Journal of Applied Bacteriology 78:655-662. Lawton JW, Shortridge KF, Wong RL, Ng MH. (1979) Interferon synthesis by human colostral leucocytes. Archives of Disease in Childhood 54:127-130. LeFranc-Millot C, Vercaigne-Marko D, Wal J.-M, et al. (1996) Comparison of the IgE titers to bovine colostral G immunoglobulins and the F(ab')2 fragments in sera of patients allergic to milk. Int Arch Allergy Immunol. 110:156-162. Leszek J, Inglot AD, Janusz M, Lisowski J, Krukowska K, Georgiades JA. (1999) Colostrinin: a Proline-Rich Polypeptide (PRP) Complex Isolated from Ovine Colostrum for Treatment of Alzheimer's Disease. A Double - Blind Placebo-Controlled Study. Archivum Immunologiae et Therapiae Experimentalis . 47(6):377-85. Lissner R, Thurmann P, Merz G, Karch, H. (1998) H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows to healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 36:239-245. Loimaranta V, Carlen A, Olsson J, Tenovuo J, Syvaoja E.-L, Korhonen H. (1998) Concentrated bovine colostral whey proteins from Streptococcus mutans/Strep. sobrinus immunized cows inhibit the adherence of Strep. mutans and promote the aggregation of mutans streptococci. Journal of Dairy Research 65:599-607. McClead RE, Butler T, Rabbani GH. (1988) Orally Administered Bovine Colostral Anti-Cholera Toxin Antibodies: Results of Two Clinical Trials. The American Journal of Medicine 85:811-816. Michalek SM, McGhee JR. (1977) Effective immunity to dental caries: passive transfer to rats to antibodies to Streptococcus mutans elicits protection. Infection and Immunity 17:644-650. Michalek SM, McGhee JR, Babb JL. (1978) Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infection and Immunity . 19:217-224. Mitra AK, Mahalanabis D, Ashraf H, Unicomb L, Eeckels R, Tzipori S. (1995) Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial. Acta Paediatr . 84:996-1001. Moro I, Abo T, Crago SS, Komiyama K, Mestecky J. (1985) Natural Killer Cells in Human Colostrum. Cellular Immunology . 93:467-474. Naber P, et al. (1996) Inhibition of adhesion of Clostridium difficile to caco-2 cells. Immunology and Medical Microbiology . 14:205-209. Ouwehand A, Salminen S, Skurnik M, Conway P. (1997) Inhibition of pathogen adhesion by B-lactoglobulin. International Dairy Journal . 7:685-692. Ogra P, Losonsky G, Fishaut M. (1983) Colostrum-derived immunity and maternal-neonatal interaction. New York Academy of Science 409:82-95. Ogra SS, Ogra PL. (1978) Immunologic aspects of human colostrum and milk. The Journal of Pediatrics . 92:546-549. Palmer EL, Gary Jr. GW, Black R, Martin ML. (1980) Antiviral activity of colostrum and serum immunoglobulins a and g. Journal of Medical Virology. 5:123-129. Parodi PW. (1996) Milk fat components: possible chemopreventive agents for cancer and other diseases. The Australian Journal of Dairy Technology . 51:24-32. Petschow B, Talbott R. (1994) Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastic acid and digestive enzymes. Journal of Pediatric Gastroenterology and Nutrition . 19:228-235. Plettenberg A, Stoehr.A, Stellbrink.J, Albrecht.H, Meigel W. (1993) A preparation from bovine colostrum in the treatment of HIV-posotive patients with chronic diarrhea. Clinical Investigator 71:42-45. Pincus C, Nussenweig V. (1971) Regulation of the Immune Response: Suppressive and enhancing effects of passively administered antibody. Journal of Experimental Medicine . 133:987-1003. Pironi L, Miglioli M, Ruggeri E, et al. (1990 ) Relationship between intestinal permeability to EDTA and Inflammatory activity in asymptomatic patients with Crohn's disease. Digestive Diseases and Sciences . 35(5):582-8. Quigley JD, Martin KR, Dowlen HH, Wallis LB, Lamar K. (1994) Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. Journal of Dairy Science. 77:264-269. Rautiainen E. (1998) The prevalence of Mycoplasma hyopneumoniae in pig herds in western Finland based on the demonstration of antibodies in colostrum by ELISA. Acta Vet Scand. 39:325-330. Ritchie D, Becker E. (1994) Update on the management of intestinal cryptosporidiosis in AIDS. The Annals of Pharmacotherapy . 28:767-778. Robert Service. (1994) Triggering the First Line of Defense. Research News . 265. Rump JA, Arndt R, Arnold A, et al. (1992)Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clinical Investigator . 70:588-594. Saif L, Smith K. (1985) Enteric viral infections of calves and passive immunity. Journal of Dairy Science . 68:206-228. Sandholm M, Honkanen-Buzalski T. (1979) Colostral trypsin-inhibitor capacity in different animal species. Acta Vett.Scand . 20:469-476. Sarker S, Casswall T, Mahalanabis M, et al. (1998) Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatric Journal of Infectious Disease . 17:1149-54. Savilahti E, Tainio VM, Salmenpera L, Arjomaa P, Kallio M, Perheentupa J, Siimes MA. (1991) Low colostral IgA associated with cow's milk allergy. Acta Pediatr Scan . 80:1207-1213. Selo I, Clement G, Bernard H, et al. (1999) Allergy to bovine B-lactoglobulin: specificity of human IgE to tryptic peptides. Clinical and Experimental Allergy 29:1055-1063. Shearman D. (1972) The demonstration and function of antibodies in the gastrointestinal tract. Gut . 13(6):483-99. Shortridge K, Lawton J, Choi E. (1990) Protective potential of colostrum and early milk against prospective influenza viruses. Journal of Tropical Pediatrics . 36(2):94-5. Siber G. (1992) Immune globulin to prevent nosocomial infection. New England Journal of Medicine . 327(4):269-71. Stephen W, Dichtelmuller H, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Chemical Clinical Biochemistry 28:19-23. Staroscik K, Janusz M, Zimecki M, Wieczorek Z, Lisowski J. (1983) Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molecular Immunology . 12:1277-1282. Swarbrick ET. (1992) The handling of ingested antigens. Am J Trop Med Hyg . 47(3):276-83. Tacket CO, Binion SB, Bostwick E, Losonsky G, Roy MJ, Edelman R. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg . 47:276-283, 1992. Takahashi, T. and et al. (1998) Effects of Orally Ingested Bifidobacterium longum on the Mucosal IgA response of Mice to Dietary Antigens. Biosci Biotechnol Biochem . 62(1):10-5. Tejada-Simon M, Lee J, Ustunol Z, Pestka J.( 1999) Ingestion of yogurt containing lactobacillus acidophilus and bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. Journal of Dairy Science 82:649-660. Tyler J, Stevens B, Hostetler D, Holle J, Denbigh J. (1999) Colostral immunoglobulin concentrations in holstein and guernsey cows. American Journal of Veterinary Research . 60(9):1136-9. Tzipori S, Roberton D, Chapman C. (1986) Remission of diarrhoea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. British Medical Journal . 293(6557):1276-7. Ulcova-Gallova Z, Fialova P, Krauz V. (1994) Immunologic factors in human colostrum and milk. Casopis Lekaru Ceskych 133:275-276. Ungar BLP, Ward DJ, Fayer R, Quinn CA. (1990)Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology . 98:486-489. Ushijima H, Dairaku M, Honnma H, Mukoyama A, Kitamura T. (1990) Immunoglobulin components and anti-viral activities in bovine colostrum. 64:274-279. Veselsky L, Cechova D, Jonakova V. (1978) Secretion and Immunochemical Properties of the Trypsin Inhibitor from Bovine Colostrum. Hoppe-Seyler's Z. Physiol. Chem . 359:873-878. Waldman RH, Stone J, Lazzell V, et al. (1983) Oral route as method for immunizing against mucosal pathogens. Ann N Y Acad Sci . Jun 30;409:510. Walker M. (1999)Bovine colostrum offers broad-spectrum benefits for wide-ranging ailments. Medical Journalist Report of Innovative Biologics: Townsend Letters for Doctors and Patients . 74-80. Walker M. (1997) Homeostatic soil organisms support immune system functions from the ground up. Townsend Letters for Doctors and Patients . Walker M. (1995) Infectious bugs are back but there's a remedy. Townsend Letters for Doctors and Patients . Ylitalo S, Uhari M, Rasi S, Pudas J, Leppaluoto J. 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